AR 2009 (Eng), Publications

Publications

Annual Report 2009

Among the 78 original articles, we report here in the following list a representative sample involving the different themes of the Subprograms. It is noted that, as mentioned above, INCTTOX sum upon accomplishment what has been produced, understanding that the recognition for its approval was because of what the various investigators involved had achieved throughout their careers.

It should be pointed that of the 78 original articles produced, 90% refer to the themes included in the Subprograms: BIOCHEMISTRY AND MOLECULAR BIOLOGY, PHYSIOPATHOLOGY AND IMMUNOLOGY. Thus, an extensive assessment was not necessary, because scientific production is self-analytical.

  1. ALVARENGA L, MOREAU V, FELICORI L, NGUYEN C, DUARTE C, CHAVEZ-OLORTEGUI C, MOLINA F, MARTIN-EAUCLAIRE MF, GRANIER C. Design of antibody-reactive peptides from discontinuous parts of scorpion toxins. Vaccine 28: 970-80, 2010. PDF
  2. ANDRICH F, CARNIELLI JBT, CASSOLI JS, LAUTNER RQ, SANTOS RAS, PIMENTA AMC, DE LIMA ME, FIGUEIREDO SG. A Potent Vasoactive Cytolysin Isolated from Scorpaena Plumieri Scorpionfish Venom. Submitted Toxicon.
  3. BATISTA IF, RAMOS OH, VENTURA JS, JUNQUEIRA-DE-AZEVEDO IL, HO PL, CHUDZINSKI-TAVASSI AM. A new Factor Xa inhibitor from Amblyomma cajennense with a unique domain composition. Arch Biochem Biophys 493: 151-156, 2010. PDF
  4. CALDERON LA, JARDIM I S, ZULIANI JP, ALMEIDA E SILVA A, CIANCAGLINI P, SILVA LHP, STABELI RG. Amazonian biodiversity and drug development for neglected diseases: past, present and future perspectives. J Braz Chem Soc 20: 1011-23, 2009.
  5. CARVALHO LV, RUIZ RC, MARENGO EB, MATOS JR, RIBEIRO OG, TAMBOURGI DV, FANTINI MCA, SANT’ANNA OA. Immunological Parameters Related to the Adjuvant Effect of Ordered Mesoporous Silica SBA-15. Submitted Vaccine.
  6. DE ALMEIDA CMC, DA SILVA CL, PENA-COUTO H, MOTHÉ-SCOCARD RC, DA ROCHA DG, SENTINELLI LP, KIPNIS TL, DIAS DA SILVA W. Development of process to produce polyvalent IgY antibodies anti-African snake venom. Toxicon 52: 293-301, 2008.
  7. DE SANTI FERRARA GI, FERNANDES-PEDROSA MDE F, JUNQUEIRA-DE-AZEVEDO IDE L, GONÇALVES-DE-ANDRADE RM, PORTARO FC, MANZONI-DE-ALMEIDA D, MURAKAMI MT, ARNI RK, VAN DEN BERG CW, HO PL, TAMBOURGI DV. SMase II, a new sphingomyelinase D from Loxosceles laeta venom gland: Molecular cloning, expression, function and structural analysis. Toxicon 53:743-753, 2009. PDF
  8. DIAS DA SILVA W, TAMBOURGI DV. IgY: A promising antibody for use in immunodiagnostic and in immunotherapy. Vet Immunol Immunopathol 2010 Jan 7 [Epub ahead of print].
  9. DIAS-LOPES C, GUIMARÃES G, FELICORI L, FERNANDES P, EMERY L, KALAPOTHAKIS E, NGUYEN C, MOLINA F, GRANIER C, CHÁVEZ-OLÓRTEGUI C. A protective immune response against lethal, dermonecrotic and hemorrhagic effects of Loxosceles intermedia venom elicited by a 27-residue peptide. Toxicon 55: 481-7, 2010. PDF
  10. DUARTE CG, ALVARENGA LM, DIAS-LOPES C, MACHADO-DE-AVILA RA, NGUYEN C, MOLINA F, GRANIER C, CHÁVEZ-OLÓRTEGUI C. In vivo protection against Tityus serrulatus scorpion venom by antibodies rose against a discontinuous synthetic epitope. Vaccine 28: 1168-1176, 2010.
  11. FELICORI L, FERNANDES PB, GIUSTA MS, DUARTE CG, KALAPOTHAKIS E, NGUYEN C, MOLINA F, GRANIER C, CHÁVEZ-OLÓRTEGUI C. An in vivo protective response against toxic effects of the dermonecrotic protein from Loxosceles intermedia spider venom elicited by synthetic epitopes. Vaccine 27: 4201-8, 2009.
  12. FERREIRA RN, RATES B, RICHARDSON M, GUIMARÃES BG, SANCHEZ EO, PIMENTA AM, NAGEM RA. Complete amino-acid sequence, crystallization and preliminary X-ray diffraction studies of leucurolysin-a, a nonhaemorrhagic metalloproteinase from Bothrops leucurus snake venom. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65:798-801, 2009.
  13. FURTADO MD, CARDOSO ST, SOARES OE, PEREIRA AP, FERNANDES DS, TAMBOURGI DV, SANT’ANNA OA. Antigenic cross-reactivity and immunogenicity of Bothrops venoms from snakes of the Amazon region. Toxicon 55:881-887, 2010.
  14. GEBRIM LC, MARCUSSI S, MENALDO DL, DE MENEZES CSR, NOMIZO A, HAMAGUCHI A, SILVEIRA-LACERDA EP, HOMSI-BRANDEBURGO MI, SAMPAIO SV, SOARES AM, RODRIGUES VM. Antitumor effects of snake venom chemically modified Lys49 phospholipase A2-like BthTX-I and a synthetic peptide derive ed from its C-terminal region. Biologicals 37: 222-229, 2009.
  15. GOMES HL, ANDRICH F, MAUAD H, SAMPAIO KN, DE LIMA ME, FIGUEIREDO SG, MOYSÉS MR. Cardiovascular effects of scorpionfish (Scorpaena plumieri) venom. Toxicon 55:580-9, 2010.
  16. GUTIERREZ JM, FAN HW, SILVERA CL, ANGULO Y. Stability, distribution and use of antivenoms for snakebite envenomation in Latin America: report of a workshop. Toxicon 53: 625-630, 2009.
  17. GUTIÉRREZ JM, WILLIAMS D, FAN HW, WARRELL DA. Snakebite envenoming from a global perspective: Towards an integrated approach. Submitted Toxicon.
  18. JARED C, ANTONIAZZI MM, JORDÃO AEC, SILVA JRMC, GREVEN H, RODRIGUES MT. Parotoid macroglands in toad (Rhinella jimi): Their structure and functioning in passive defence. Toxicon 54: 197-207, 2009.  PDF
  19. ASUNSKAIA E, RIBEIRO SC, MANICHEVA O, GOMES LL, SUFFYS PN, MOKROUSOV I, FERRAZOLI L, ANDRADE MR, KRITSKI A, OTTEN T, KIPNIS TL, DA SILVA WD, VISHNEVSKY B, GOMES HM, BAPTISTA IF, NARVSKAYA O. Emerging multi-drug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence. Microbes and Infection 2010 Mar 7 [Epub ahead of print].
  20. LUCAS SM, BRESCOVIT AD, PAULA FS. Eine Merkwürdige Erscheinung: Verdoppelung der Spermathek bei Acanthoscurria suina POCOCK 1903 (Araneae, Mygalomorphae, Theraphosidae). Arachne 14: 12-14, 2009.
  21. MARANDINO M, OLIVEIRA AD, MORTENSEN M. Discussing biodiversity in dioramas: a powerful tool to museum education. International Council of Museums 29: 30-36, 2009. PDF
  22. MARENGO EB, COMMODARO AG, PERON JP, DE MORAES LV, PORTARO FC, BELFORT R JR, RIZZO LV, SANT’ANNA OA. Administration of Mycobacterium leprae rHsp65 Aggravates Experimental Autoimmune Uveitis in Mice. PLoS ONE 4: e7912, 2009. PDF
  23. MARENGO EB, DE MORAES LV, FARIA M, FERNANDES BL, CARVALHO LV, TAMBOURGI DV, RIZZO LV, PORTARO FCV, CAMARGO ACM, SANT’ANNA OA. Administration of M. leprae Hsp65 Interferes with the Murine Lupus Progression. PLoS ONE 3: e3025, 2008.
  24. MATAVEL A, FLEURY C, OLIVEIRA LC, MOLINA F, DE LIMA ME, CRUZ JS, CORDEIRO MN, RICHARDSON M, RAMOS CH, BEIRÃO PS. Structure and activity analysis of two spider toxins that alter sodium channel inactivation kinetics. Biochemistry 48:3078-88, 2009. PDF
  25. MOREIRA, K.G. ; PRATES, M. V. ; ANDRADE, F. A. C. ; SILVA, L.P. ; NAVES, L. A. ; BEIRÃO, P. S. L. ; KUSHMERICK, C. ; BLOCH JR, C. Frontoxins, three-finger toxins from Micrurus frontalis venom, decrease miniature endplate potential amplitude at frog neuromuscular junction. Accepted Toxicon.
  26. NUNES K, CORDEIRO M, RICHARDSON M, BORGES, M.H, DINIZ S., CARDOSO V, TOSTES R, DE LIMA ME, WEBB RC, LEITE R. The relaxation effect of PnTx2-6 toxin from Phoneutria nigriventer spider in cavernosal strips is improved by Sildenafil. Submitted J Sex Med.
  27. OKAMOTO CK, GONÇALVES-DE-ANDRADE RM, QUEIROZ GP, GUTIEREZ VP, DE ALMEIDA DM, CURY Y, BERTANI R, PORTARO FC, TAMBOURGI DV. Ctenus medius and Phoneutria nigriventer spiders venoms share noxious pro-inflammatory activities. J Med Entomol 46: 58-66, 2009.
  28. OLIVEIRA AK, PAES LEME AF, ASEGA AF, CAMARGO ACM, FOX JW, SERRANO SMT. New insights into the structural elements involved in the skin hemorrhage induced by snake venom metalloproteinases. Submitted Thromb Haemost.
  29. PONTE CG, NÓBREGA EL, FERNANDES VC, DIAS DA SILVA W, SUAREZ-KURTZ G. Inhibition of the myotoxic activities of three African Bitis venoms (B. rhinoceros, B. arietans, B. nasicornis) by a polyvalent antivenom Toxicon 55: 536-540, 2009.
  30. SANTOS DM, VERLY RM, PILÓ-VELOSO D, DE MARIA M, DE CARVALHO MA, CISALPINO PS, SOARES BM, DINIZ CG, FARIAS LM, MOREIRA DF, FRÉZARD F, BEMQUERER MP, PIMENTA AM, DE LIMA ME. LyeTx I, a potent antimicrobial peptide from the venom of the spider Lycosa erythrognatha. Amino Acids 2009 Nov 28.
  31. SEIBERT CS, SANTORO ML, TAMBOURGI DV, SAMPAIO SC, TAKAHASHI HK, PERES CM, CURI R, SANO-MARTINS IS. Lonomia obliqua (Lepidoptera, Saturniidae) caterpillar bristle extract induces direct lysis by cleaving erythrocyte membrane glycoproteins. Toxicon 2010 Feb 9 [Epub ahead of print]
  32. TAMBOURGI DV, GONÇALVES-DE-ANDRADE RM, VAN DEN BERG CW. Loxoscelism: from basic research to the proposal of new therapies. Toxicon 2010 Feb 6 [Epub ahead of print].
  33. TANJONI I, EVANGELISTA K, DELLA-CASA MS, BUTERA D, MAGALHÃES GS, BALDO C, CLISSA PB, FERNANDES I, EBLE J, MOURA-DA-SILVA AM. Different regions of the class p-iii snake venom metalloproteinase jararhagin are involved in binding to -2-1 integrin and collagen. Accepted Toxicon.
  34. TEIXEIRA C, CURY Y, MOREIRA V, PICOLO G, CHAVES F. Inflammation induced by Bothrops asper venom. Toxicon 54: 988-97, 2009. PDF
  35. TORRES FS, SILVA CN, LANZA LF, SANTOS AV, PIMENTA AMC, DE LIMA ME, DINIZ MRV. Functional expression of a recombinant toxin rPnTx2-6 active in erectile function in rat. Submitted Toxicon.
  36. VERANO-BRAGA T, FIGUEIREDO-REZENDE F, MELO MN, LAUTNER RQ, GOMES ERM, MATA-MACHADO LT, MURARI A, ROCHA-RESENDE C, DE LIMA ME, SANTOS RAS, GUATIMOSIM S, PIMENTA AMC. Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): a new agonist of B2 kinin receptor. Submitted Toxicon.
  37. WAISMAM K, CHUDZINSKI-TAVASSI AM, CARRIJO-CARVALHO LC, PACHECO MT, FARSKY SH. Lopap: a non-inflammatory and cytoprotective molecule in neutrophils and endothelial cells. Toxicon 53:652-9, 2009. PDF
  38. ZAMBONI CB, METAIRON S, SUZUKI MF, FURTADO MF, SANT’ANNA OA, TAMBOURGI DV. Quantitative evaluation of blood elements by neutron activation analysis in mice immunized with Bothrops snake venoms. J. Radioanal. Nucl. Chem. 282: 37-39, 2009.
  39. ZULIANI JP, KAYANO AM, ZAQUEO KD, NETO AC, SAMPAIO SV, SOARES AM, STABELI RG. Snake venom L-amino acid oxidases: Some consideration about its functional characterization. Protein Pept Lett 16: 908-912, 2009.
  40. ZYCHAR BC, DALE CS, DEMARCHI DS, GONÇALVES LR. Contribution of metalloproteases, serine proteases and phospholipases A2 to the inflammatory reaction induced by Bothrops jararaca crude venom in mice. Toxicon 55: 227-234, 2010.



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